编辑日期：2023-02-27作者：燕阳医疗
近日，由中国医科大学附属第一医院齐瑞群，陈洪铎，李珊珊，高兴华等多位教授根据临床试验撰写的英文文献：“ Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy”（通过单一病灶清除多发性皮肤疣：轻度局部热疗与冷冻治疗的随机比较评估）已在皮肤领域临床研究最高影响力期刊-美国皮肤病学会杂志《JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY》发布。
Rui-Qun Qi，Hong-Duo Chen, Shanshan Li , Xing-Hua Gao，et al. Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy. J Am Acad Dermatol. 2022 Aug 4;S0190-9622(22)02420-3. doi: 10.1016/j.jaad.2022.07.043. Online ahead of print. PMID: 35934211
影响因子高达15.487
节选自文献：Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy
该文在介绍局部温热治疗可诱导免疫反应会启动对含有相同人乳头瘤病毒类型的其他非靶向或远程病变的疣体免疫清除的基础上，以两个中心、时长4个月、评估盲法随机对照试验；借助研究成果转化设备-红外特定波光能温热治疗仪，通过对多发性皮肤疣患者靶点应用局部温热疗法或冷冻疗法来评估整体清除疗效为论点；再一次验证了局部温热可使机体建立针对病原的免疫识别，从而达到清除疣体的疗效。
注释：
Calculations are made on intent-to-treat populations.
CI, Confidence interval; SD, standard deviation; VAS, visual analog scale.
*The rate difference and the 95% confidence interval for the difference between 2 independent arms, calculated according to the Wilson
procedure with a correction for continuity.
y Mixed types: patients with both diagnosed verruca vulgaris and plantar warts.
z t test on the VAS scores collected during treatment at day 1, week 2, and week 4, for the 2 groups of patients.
更以详细的数据排列，对比分析了局部温热与冷冻疗法治疗寻常疣、跖疣、尖锐湿疣的临床效果，通过对照两种治疗方式（局部温热&冷冻疗法）的非靶向病灶和靶点病灶的清除率及其他治疗副作用，总结了局部温热疗法可单靶点治疗人乳头瘤病毒感染性皮肤疣的效果优势与治愈率优势，并通过了试验中心协作为温热免疫诱导疗法的进一步大范围应用提供了全面的专业学术支撑。
参考文献：
1. De Planell-Mas E, Mart?ınez-Garriga B, Zalacain AJ, Vinuesa T,Vi~ nas M. Human papillomaviruses genotyping in plantar warts.J Med Virol. 2017;89(5):902-907.
2. Huo W, Gao YL, Wang HY, et al. Local hyperthermia versus cryotherapy for treatment of plantar warts: a prospective multi-centre non-randomized concurrent controlled clinicaltrial. Acta Derm Venereol. 2022;102:adv00655.
3. Jean LB, Julie VS, Lorenzo C. Dermatology. 4th ed. Elsevier; 2018.
4. Huo W, Gao XH, Sun XP, et al. Local hyperthermia at 44degrees C for the treatment of plantar warts: a randomized,patient-blinded, placebo-controlled trial. J Infect Dis. 2010;201(8):1169-1172.
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